ABSTRACT

 

ABSTRACT

Medicinal chemistry provides pharmacy students with a thorough understanding of drug mechanisms of action, structure-activity relationships (SAR), acid-base and physicochemical properties, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles.

The first medical chemistry courses were taught in Jena in the early 1600s and The New Chemical Medicine Invented by Paracelsus was published in the Ottoman Empire shortly thereafter.

Medicinal Chemistry Research is a journal for the prompt disclosure of novel experimental achievements in the many facets of drug design, drug discovery, and the elucidation of mechanisms of action of biologically active compounds.

Medicinal chemistry is a specialized area with an emphasis on the study of drug design, drug synthesis, and pharmaceutical and biomedical analysis.

Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and “biologics” (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones etc.). Inorganic and organometallic compounds are also useful as drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cisplatin as well as gallium.